Advanced metastatic cancer occurs when malignant tumor cells from the primary cancer site spread to other organs or parts of the body and form masses of abnormal cells (metastases) in the new site. Cancer metastases account for over 90% of cancer deaths. However currently there are no effective and selective treatments that directly target metastatic cancer. Surgical resection of widespread metastases is generally not feasible, whereas various classes of chemotherapeutic drugs delivered systemically often have severe side effects due to the lack of tumor targeting. This limitation often renders current chemotherapy under debate regarding their use in the treatment of certain advanced cancers. Thus it is urgent to find innovative strategies to precisely deliver the drugs to the tumor sites. The inherent capacity of hUC-MSC to home towards the tumor microenvironment provides unique opportunity as delivery vehicle to efficiently target therapeutics to cancer with minimal side effects.